Endocannabinoids, Related Compounds and Their Metabolic Routes

Endocannabinoids, Related Compounds and Their Metabolic Routes

However, over the last 20 years eCBs-related drugs have indeed been commercially available, such as Cesamet® (nabilone, a synthetic cannabinoid) and Marinol® (dronabinol, a synthetic THC), that are preparations used to treat nausea and vomiting associated to cancer chemotherapy. The latter drug is also prescribed to manage the loss of appetite in people with acquired immunodeficiency syndrome (AIDS). In addition Sativex®, a medicine that contains THC and cannabidiol at a 1:1 ratio, has been licensed for the symptomatic treatment (pain, spasticity and incontinence) of multiple sclerosis patients in a (ever-growing) number of countries (e.g., United Kingdom, Canada, New Zealand and United States of America). Furthermore, PEA is currently marketed to cure neuropathic (Normast®) and pelvic (Pelvilen®) pain, and is one of the main components of a cream (Physiogel®) used for inflamed or irritated skin of subjects with atopic dermatitis.

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