Connection Between Endocannabinoids system and the Brain- Gut Axis

STUDY The role of the endocannabinoid system in the brain-gut axis

Cannabinoids are prescribed for GI conditions, particularly nausea and vomiting, as an appetite stimulant and for the treatment of visceral pain. There is evidence that direct or indirect activation of CB1, and possibly CB2, inhibits visceral sensitivity and pain in rodents. Central side effects such as drowsiness and heightened awareness have been reported. Recently developed ligands of CB2 and peripherally acting ligands of CB1 and CB2 have the potential to alleviate GI symptoms without CNS side effects.
Endocannabinoids, Related Compounds and Their Metabolic Routes

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